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KMID : 0387420170280030145
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Korean Society of Oriental Neuropsychiatry
2017 Volume.28 No. 3 p.145 ~ p.156
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A Review on Experimental Studies of Parkinson's Disease in Korean Medical Journals
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Joo Hwan-soo
Yu Ok-Cheol
Han Chang
Yang Kyu-Jin
Lee Sung-Yub
Moon Hye-Yeon
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Abstract
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Objectives: The purpose of this study is to review experimental studies of Parkinson's Disease in Korean medical journals, which have been published since 1990.
Methods: Experimental studies related to Parkinson's disease published in Korean medical journals, registered with Korea research foundation, were searched. Articles were grouped into journal of publication, subject, and publication year. Experimental study subjects and models were analysed.
Results and Conclusions: Twenty-two articles about experimental studies of Parkinson's Disease in Korean medical journals were included in our review. There were 13 articles in which herbs were used for treatment, 4 articles in which bee venom was used for treatment, 4 articles in which acupuncture was used for treatment, and 1 article in which pharmacopuncture was used for treatment. Most of the studies used experimental models of MPTP-induced Parkinson's disease and MTT assay was used to analyse cell toxicity and cell viability. Pole test, rotarod test, Morris water maze test, and forced swimming test were commonly used to analyse MPTP-induced behavioral deficits in animals. Analysis on experimental studies of Parkinson's disease was categorized into the subjects of dopaminergic cell protective effect, cell-apoptosis protectiveness, anti-inflammatory effect, and anti-oxidative effect.
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KEYWORD
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Parkinson's disease , Experimental study , Korean medicine , Herbal medicine , Acupuncture , Pharmacopuncture
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